Now showing items 1-20 of 4808

    • 04. Experiential Integrative Approaches to Heart Health 

      Haramati, Adi; Eisenberg, David; Devries, Stephen (Global Advances in Health and Medicine, 2013)
      Focus Areas: Integrative Approaches to Care, Experiential Workshop This session will highlight two of the most important, yet frequently overlooked, determinants of heart health: mind-body interactions and nutrition. These ...
    • 140 Reversing the Epidemic of HIV-1C in Southern Africa with Treatment as Prevention 

      Essex, M. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)
      The epidemic of HIV-1C in southern Africa is characterized by a sustained prevalence that is substantially higher than for other epidemics of HIV/AIDS. Perhaps the best correlate of transmission is high viral load (HVL), ...
    • A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose 

      Farid, Huma; Wojcik, Monica H.; Christopher, Kenneth B. (Oxford University Press, 2011)
      Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic ...
    • 2-Year BMI Changes of Children Referred for Multidisciplinary Weight Management 

      Cheng, Jennifer K.; Wen, Xiaozhong; Coletti, Kristen D.; Cox, Joanne E.; Taveras, Elsie M. (Hindawi Publishing Corporation, 2014)
      Objective. To examine body mass index (BMI) changes among pediatric multidisciplinary weight management participants and nonparticipants. Design. In this retrospective database analysis, we used multivariable mixed effect ...
    • The 2015 Bioinformatics Open Source Conference (BOSC 2015) 

      Harris, Nomi L.; Cock, Peter J. A.; Lapp, Hilmar; Chapman, Brad; Davey, Rob; Fields, Christopher; Hokamp, Karsten; Munoz-Torres, Monica (Public Library of Science, 2016)
      The Bioinformatics Open Source Conference (BOSC) is organized by the Open Bioinformatics Foundation (OBF), a nonprofit group dedicated to promoting the practice and philosophy of open source software development and open ...
    • 24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex 

      Lim, Andrew S. P.; Srivastava, Gyan P.; Yu, Lei; Chibnik, Lori B.; Xu, Jishu; Buchman, Aron S.; Schneider, Julie A.; Myers, Amanda J.; Bennett, David A.; De Jager, Philip L. (Public Library of Science, 2014)
      Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of ...
    • 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. 

      Wright, J Michael; Schwartz, Joel David; Vartiainen, Terttu; Mäki-Paakkanen, Jorma; Altshul, Larisa M.; Harrington, Joseph J; Dockery, Douglas W. (2002)
      There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ...
    • 3D Traction Forces in Cancer Cell Invasion 

      Koch, Thorsten M.; Münster, Stefan; Bonakdar, Navid; Butler, James Preston; Fabry, Ben (Public Library of Science, 2012)
      Cell invasion through a dense three-dimensional (3D) matrix is believed to depend on the ability of cells to generate traction forces. To quantify the role of cell tractions during invasion in 3D, we present a technique ...
    • (A)Symmetric Stem Cell Replication and Cancer 

      Dingli, David; Traulsen, Arne; Michor, Franziska L. (Public Library of Science, 2007)
      Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Since cellular replication is associated with an inherent risk of mutagenesis, tissues are maintained by a small group of stem ...
    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...
    • Abacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Women 

      MacLeod, Iain James; Rowley, Christopher Francis; Lockman, Shahin; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Makhema, Joseph Moeketsi; Essex, Myron Elmer; Shapiro, Roger L. (International AIDS Society, 2012)
      Background: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory ...
    • ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells 

      Wee, Boyoung; Pietras, Alexander; Ozawa, Tatsuya; Bazzoli, Elena; Podlaha, Ondrej; Antczak, Christophe; Westermark, Bengt; Nelander, Sven; Uhrbom, Lene; Forsberg-Nilsson, Karin; Djaballah, Hakim; Michor, Franziska; Holland, Eric C. (Nature Publishing Group, 2016)
      Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability mediated by the ABC transporter ABCG2 ...
    • Aberrant islet unfolded protein response in type 2 diabetes 

      Engin, Feyza; Nguyen, Truc; Yermalovich, Alena; Hotamisligil, Gökhan S. (Nature Publishing Group, 2014)
      The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating evidence indicates that the canonical UPR is ...
    • Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity 

      De, Subhajyoti; Shaknovich, Rita; Riester, Markus; Elemento, Olivier; Geng, Huimin; Kormaksson, Matthias; Jiang, Yanwen; Woolcock, Bruce; Johnson, Nathalie; Polo, Jose M.; Cerchietti, Leandro; Gascoyne, Randy D.; Melnick, Ari; Michor, Franziska L. (Public Library of Science, 2013)
      Despite mounting evidence that epigenetic abnormalities play a key role in cancer biology, their contributions to the malignant phenotype remain poorly understood. Here we studied genome-wide DNA methylation in normal ...
    • Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes 

      Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; Omarjee, Saleha; Martin, Eric; Lee, Guinevere Q; Baraki, Bemuluyigza; Danroth, Ryan; McCloskey, Rosemary; Muzoora, Conrad; Bangsberg, David R; Hunt, Peter W; Goulder, Philip JR; Walker, Bruce D; Harrigan, P Richard; Martin, Jeff N; Ndung’u, Thumbi; Brockman, Mark A; Brumme, Zabrina L (BioMed Central, 2013)
      Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ...
    • Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance 

      Liew, Chong Wee; Boucher, Jeremie; Cheong, Jit Kong; Vernochet, Cecile; Koh, Ho-Jin; Mallol, Cristina; Townsend, Kristy; Langin, Dominique; Kawamori, Dan; Hu, Jiang; Tseng, Yu-Hua; Hellerstein, Marc K; Farmer, Stephen R; Goodyear, Laurie; Doria, Alessandro; Blüher, Matthias; Hsu, Stephen I-Hong; Kulkarni, Rohit N (2012)
      SUMMARY Obesity develops due to altered energy homeostasis favoring fat storage. Here we describe a novel transcription co-regulator for adiposity and energy metabolism, TRIP-Br2 (also called SERTAD2). TRIP-Br2 null mice ...
    • ABO Blood Group and Incidence of Skin Cancer 

      Xie, Jing; Qureshi, Abrar A.; Li, Yunhui; Han, Jiali (Public Library of Science, 2010)
      Background: Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and ...
    • Absolute Humidity and the Seasonal Onset of Influenza in the Continental United States 

      Shaman, Jeffrey; Pitzer, Virginia E.; Viboud, Cécile; Grenfell, Bryan T.; Lipsitch, Marc (Public Library of Science, 2010)
      Much of the observed wintertime increase of mortality in temperate regions is attributed to seasonal influenza. A recent reanalysis of laboratory experiments indicates that absolute humidity strongly modulates the airborne ...
    • An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population 

      Klein, Alison P.; Lindström, Sara; Mendelsohn, Julie B.; Steplowski, Emily; Arslan, Alan A.; Bueno-de-Mesquita, H. Bas; Fuchs, Charles S.; Gallinger, Steven; Gross, Myron; Helzlsouer, Kathy; Holly, Elizabeth A.; Jacobs, Eric J.; LaCroix, Andrea; Li, Donghui; Mandelson, Margaret T.; Olson, Sara H.; Petersen, Gloria M.; Risch, Harvey A.; Stolzenberg-Solomon, Rachael Z.; Zheng, Wei; Amundadottir, Laufey; Albanes, Demetrius; Allen, Naomi E.; Bamlet, William R.; Boutron-Ruault, Marie-Christine; Buring, Julie E.; Bracci, Paige M.; Canzian, Federico; Clipp, Sandra; Cotterchio, Michelle; Duell, Eric J.; Elena, Joanne; Gaziano, J. Michael; Giovannucci, Edward L.; Goggins, Michael; Hallmans, Göran; Hassan, Manal; Hutchinson, Amy; Hunter, David J.; Kooperberg, Charles; Kurtz, Robert C.; Liu, Simin; Overvad, Kim; Palli, Domenico; Patel, Alpa V.; Rabe, Kari G.; Shu, Xiao-Ou; Slimani, Nadia; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Van Den Eeden, Stephen K.; Vineis, Paolo; Virtamo, Jarmo; Wactawski-Wende, Jean; Wolpin, Brian M.; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Chanock, Stephen J.; Hoover, Robert N.; Hartge, Patricia; Kraft, Peter (Public Library of Science, 2013)
      Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan ...
    • Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis 

      Kim, Jonghan; Buckett, Peter D.; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Both iron and manganese absorption are regulated by iron status, ...