Browsing SPH Scholarly Articles by Keyword "Gastroenterology and Hepatology"

Now showing items 1-18 of 18

    • Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children 

      Uddin, Muhammad Ikhtear; Islam, Shahidul; Nishat, Naoshin S.; Hossain, Motaher; Rafique, Tanzeem Ahmed; Rashu, Rasheduzzaman; Hoq, Mohammad Rubel; Zhang, Yue; Saha, Amit; Harris, Jason B.; Calderwood, Stephen B.; Bhuiyan, Taufiqur Rahman; Ryan, Edward T.; Leung, Daniel T.; Qadri, Firdausi (Public Library of Science, 2016)
      Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children in resource-limited settings. ...

    • Cancer Mortality in Chinese Chrysotile Asbestos Miners: Exposure-Response Relationships 

      Wang, Xiaorong; Yano, Eiji; Lin, Sihao; Yu, Ignatius T. S.; Lan, Yajia; Tse, Lap Ah; Qiu, Hong; Christiani, David C. (Public Library of Science, 2013)
      Objective: This study was conducted to assess the relationship of mortality from lung cancer and other selected causes to asbestos exposure levels. Methods: A cohort of 1539 male workers from a chrysotile mine in China was ...

    • Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses 

      Leung, Daniel T.; Bhuiyan, Taufiqur R.; Nishat, Naoshin S.; Hoq, Mohammad Rubel; Aktar, Amena; Rahman, M. Arifur; Uddin, Taher; Khan, Ashraful I.; Chowdhury, Fahima; Charles, Richelle C.; Harris, Jason B.; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T. (Public Library of Science, 2014)
      Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured ...

    • Combination of Diabetes Risk Factors and Hepatic Steatosis in Chinese: The Cardiometabolic Risk in Chinese (CRC) Study 

      Liang, Jun; Wang, Yu; Li, Hongyan; Liu, Xuekui; Qiu, Qinqin; Qi, Lu (Public Library of Science, 2014)
      Aims Hepatic steatosis has been related to insulin resistance and increased diabetes risk. We assessed whether combination of diabetes risk factors, evaluated by the Finnish Diabetes Risk Score, was associated with risk ...

    • Combining Healthcare-Based and Participatory Approaches to Surveillance: Trends in Diarrheal and Respiratory Conditions Collected by a Mobile Phone System by Community Health Workers in Rural Nepal 

      Meyers, David J.; Ozonoff, Al; Baruwal, Ashma; Pande, Sami; Harsha, Alex; Sharma, Ranju; Schwarz, Dan; Schwarz, Ryan K.; Bista, Deepak; Halliday, Scott; Maru, Duncan S. R. (Public Library of Science, 2016)
      Background: Surveillance systems are increasingly relying upon community-based or crowd-sourced data to complement traditional facilities-based data sources. Data collected by community health workers during the routine ...

    • Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Murphy, Neil; Norat, Teresa; Ferrari, Pietro; Jenab, Mazda; Bueno-de-Mesquita, Bas; Skeie, Guri; Olsen, Anja; Tjønneland, Anne; Dahm, Christina C.; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Nailler, Laura; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Peeters, Petra H. M.; Dik, Vincent K.; Weiderpass, Elisabete; Lund, Eiliv; Garcia, Jose Ramon Quiros; Zamora-Ros, Raul; Pérez, Maria José Sánchez; Dorronsoro, Miren; Navarro, Carmen; Ardanaz, Eva; Manjer, Jonas; Almquist, Martin; Johansson, Ingegerd; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Crowe, Francesca L.; Fedirko, Veronika; Gunter, Marc J.; Riboli, Elio (Public Library of Science, 2013)
      Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the ...

    • Contribution of H. pylori and Smoking Trends to US Incidence of Intestinal-Type Noncardia Gastric Adenocarcinoma: A Microsimulation Model 

      Yeh, Jennifer M; Hur, Chin; Schrag, Deborah; Kuntz, Karen M.; Ezzati, Majid; Stout, Natasha K; Ward, Zachary Jonathan; Goldie, Sue J. (Public Library of Science, 2013)
      Background: Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important ...

    • Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Murphy, Neil; Norat, Teresa; Ferrari, Pietro; Jenab, Mazda; Bueno-de-Mesquita, Bas; Skeie, Guri; Dahm, Christina C.; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Racine, Antoine; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Siersema, Peter; van Duijnhoven, Franzel; Peeters, Petra H. M.; Hjartaker, Anette; Engeset, Dagrun; González, Carlos A.; Sánchez, Maria-José; Dorronsoro, Miren; Navarro, Carmen; Ardanaz, Eva; Quirós, José R.; Sonestedt, Emily; Ericson, Ulrika; Nilsson, Lena; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Crowe, Francesca L.; Fedirko, Veronika; Wark, Petra A.; Chuang, Shu-Chun; Riboli, Elio (Public Library of Science, 2012)
      Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored ...

    • Genetic Variation in the Base Excision Repair Pathway, Environmental Risk Factors, and Colorectal Adenoma Risk 

      Corral, Roman; Lewinger, Juan Pablo; Joshi, Amit D.; Levine, A. Joan; Vandenberg, David J.; Haile, Robert W.; Stern, Mariana C. (Public Library of Science, 2013)
      Cigarette smoking, high alcohol intake, and low dietary folate levels are risk factors for colorectal adenomas. Oxidative damage caused by these three factors can be repaired through the base excision repair pathway (BER). ...

    • Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer 

      Figueiredo, Jane C.; Hsu, Li; Hutter, Carolyn M.; Lin, Yi; Campbell, Peter T.; Baron, John A.; Berndt, Sonja I.; Jiao, Shuo; Casey, Graham; Fortini, Barbara; Chan, Andrew T.; Cotterchio, Michelle; Lemire, Mathieu; Gallinger, Steven; Harrison, Tabitha A.; Le Marchand, Loic; Newcomb, Polly A.; Slattery, Martha L.; Caan, Bette J.; Carlson, Christopher S.; Zanke, Brent W.; Rosse, Stephanie A.; Brenner, Hermann; Giovannucci, Edward L.; Wu, Kana; Chang-Claude, Jenny; Chanock, Stephen J.; Curtis, Keith R.; Duggan, David; Gong, Jian; Haile, Robert W.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Jenkins, Mark A.; Kolonel, Laurence N.; Qu, Conghui; Rudolph, Anja; Schoen, Robert E.; Schumacher, Fredrick R.; Seminara, Daniela; Stelling, Deanna L.; Thibodeau, Stephen N.; Thornquist, Mark; Warnick, Greg S.; Henderson, Brian E.; Ulrich, Cornelia M.; Gauderman, W. James; Potter, John D.; White, Emily; Peters, Ulrike (Public Library of Science, 2014)
      Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk ...

    • Impact of the Adipokine Adiponectin and the Hepatokine Fetuin-A on the Development of Type 2 Diabetes: Prospective Cohort- and Cross-Sectional Phenotyping Studies 

      Stefan, Norbert; Sun, Qi; Fritsche, Andreas; Machann, Jürgen; Schick, Fritz; Gerst, Felicia; Jeppesen, Charlotte; Joost, Hans-Georg; Hu, Frank B.; Boeing, Heiner; Ullrich, Susanne; Häring, Hans-Ulrich; Schulze, Matthias B. (Public Library of Science, 2014)
      Background: Among adipokines and hepatokines, adiponectin and fetuin-A were consistently found to predict the incidence of type 2 diabetes, both by regulating insulin sensitivity. Objective: To determine to what extent ...

    • Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model 

      Shaw-Saliba, Kathryn; Thomson-Luque, Richard; Obaldía, Nicanor; Nuñez, Marlon; Dutary, Sahir; Lim, Caeul; Barnes, Samantha; Kocken, Clemens H. M.; Duraisingh, Manoj T.; Adams, John H.; Pasini, Erica M. (Public Library of Science, 2016)
      Malaria is one of the most significant tropical diseases, and of the Plasmodium species that cause human malaria, P. vivax is the most geographically widespread. However, P. vivax remains a relatively neglected human ...

    • Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer 

      Hiraki, Linda T.; Joshi, Amit D.; Ng, Kimmie; Fuchs, Charles S.; Ma, Jing; Hazra, Aditi; Peters, Ulrike; Karlson, Elizabeth W.; Giovannucci, Edward; Kraft, Peter; Chan, Andrew T. (Public Library of Science, 2014)
      Background: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. Methods: We examined main and ...

    • Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study 

      Jiang, Zhenghui Gordon; Mukamal, Kenneth; Tapper, Elliot; Robson, Simon C.; Tsugawa, Yusuke (Public Library of Science, 2014)
      Background: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol (LDL-C) or low high-density lipoprotein cholesterol (HDL-C) levels, are associated with nonalcoholic fatty ...

    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...

    • A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men 

      Strate, Lisa L.; Singh, Prashant; Boylan, Matthew R.; Piawah, Sorbarikor; Cao, Yin; Chan, Andrew T. (Public Library of Science, 2016)
      Background and Aims Data regarding smoking and alcohol consumption and risk of gastrointestinal bleeding (GIB) are sparse and conflicting. We assessed the risk of major GIB associated with smoking and alcohol consumption ...

    • Risk Factors for Childhood Stunting in 137 Developing Countries: A Comparative Risk Assessment Analysis at Global, Regional, and Country Levels 

      Danaei, Goodarz; Andrews, Kathryn G.; Sudfeld, Christopher R.; Fink, Günther; McCoy, Dana Charles; Peet, Evan; Sania, Ayesha; Smith Fawzi, Mary C.; Fawzi, Wafaie W.; Ezzati, Majid (Public Library of Science, 2016)
      Background: Stunting affects one-third of children under 5 y old in developing countries, and 14% of childhood deaths are attributable to it. A large number of risk factors for stunting have been identified in epidemiological ...

    • Tumor Necrosis Factor \(\alpha\) Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis 

      Shanmugam, Nanda Kumar Navalpur; Ellenbogen, Shiri; Trebicka, Estela; Wang, Lijian; Mukhopadhyay, Subhankar; Lacy-Hulbert, Adam; Gallini, Carey Ann; Garrett, Wendy S.; Cherayil, Bobby J. (Public Library of Science, 2012)
      Background: Abnormal expression of the liver peptide hormone hepcidin, a key regulator of iron homeostasis, contributes to the pathogenesis of anemia in conditions such as inflammatory bowel disease (IBD). Since little is ...