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Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment
(BioMed Central, 2014)
Background: Traffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups ...
Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation
(National Institute of Environmental Health Sciences, 2008)
Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at ...
Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
(BioMed Central, 2013)
Background: Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of ...
Effects of Particulate Air Pollution on Blood Pressure in a Highly Exposed Population in Beijing, China: A Repeated-Measure Study
(BioMed Central, 2011)
Background: Particulate Matter (PM) exposure is critical in Beijing due to high population density and rapid increase in vehicular traffic. PM effects on blood pressure (BP) have been investigated as a mechanism mediating ...
Air Pollution, Smoking, and Plasma Homocysteine
(National Institute of Environmental Health Sciences, 2006)
Background: Mild hyperhomocysteinemia is independently associated with an increased risk of cardiovascular disease. Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, ...
Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study
(BioMed Central, 2010)
Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ...
Blood Epigenetic Age may Predict Cancer Incidence and Mortality
(Elsevier, 2016)
Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
(Elsevier, 2015)
Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...
Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study
(Taylor & Francis, 2015)
Previous studies have reported epigenetic changes induced by environmental exposures. However, previous investigations did not distinguish 5-methylcytosine (5mC) from a similar oxidative form with opposite functions, ...
Particulate Air Pollution Exposure and Expression of Viral and Human MicroRNAs in Blood: The Beijing Truck Driver Air Pollution Study
(National Institute of Environmental Health Sciences, 2015)
Background: MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential mediators of environmental effects. In addition to human miRNAs, viral miRNAs expressed from latent viral sequences are detectable in ...