Now showing items 1-10 of 1274
Recommendations for using standardised phenotypes in genetic association studies
(BioMed Central, 2009)
Genetic association studies of complex traits often rely on standardised quantitative phenotypes, such as percentage of predicted forced expiratory volume and body mass index to measure an underlying trait of interest (eg ...
Gender inequity and age-appropriate immunization coverage in India from 1992 to 2006
(Springer Science + Business Media, 2009)
Background A variety of studies have considered the affects of India's son preference on gender differences in child mortality, sex ratio at birth, and access to health services. Less research has focused on the affects ...
PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies
(BioMed Central, 2005)
The PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees ...
Trends in nicotine yield in smoke and its relationship with design characteristics among popular U.S. cigarette brands, 1997-2005
(BMJ Publishing Group, 2007)
Objectives: To determine whether nicotine yields in the smoke of cigarettes would show an overall increase over time or an increasing trend limited to any particular market category (eg, full flavour vs light, medium (mild) ...
Trends in the Use of Cigarettes and Other Tobacco Products, 2000-2007
(American Medical Association (AMA), 2008)
Tracking the Culprit: HIV-1 Evolution and Immune Selection Revealed by Single-Genome Amplification
(Rockefeller University Press, 2009)
Early control of HIV-1 infection is determined by a balance between the host immune response and the ability of the virus to escape this response. Studies using single-genome amplification now reveal new details about the ...
The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats
(National Institute of Environmental Health Sciences, 2008)
Background: Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air.Objective ...
On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies
(Public Library of Science, 2009)
For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ...
Provider-initiated HIV testing in rural Haiti: low rate of missed opportunities for diagnosis of HIV in a primary care clinic
As HIV treatment is scaled-up in resource-poor settings, the timely identification of persons with HIV infection remains an important challenge. Most people with HIV are unaware of their status, and those who are often ...
Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial
(Public Library of Science, 2007)
Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ...