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Densely sampled viral trajectories suggest longer duration of acute infection with B.1.1.7 variant relative to non-B.1.1.7 SARS-CoV-2
(2021-02-16)
To test whether acute infection with B.1.1.7 is associated with higher or more sustained nasopharyngeal viral concentrations, we assessed longitudinal PCR tests performed in a cohort of 65 individuals infected with SARS-CoV-2 ...
Structure and Catalytic Mechanism of a Human Triacylglycerol-synthesis Enzyme
(Springer Science and Business Media LLC, 2020-05-13)
Triglycerides (triacylglycerols, TGs) store metabolic energy in organisms and have industrial uses for foods and fuels. Excessive accumulation of TGs in humans causes obesity and is associated with metabolic diseases1. TG ...
A male steroid controls female sexual behaviour in the malaria mosquito
(Springer Science and Business Media LLC, 2022-07-06)
Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones1. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both control egg ...
Psychological Consequences of the Flint Water Crisis: A Scoping Review
(Cambridge University Press (CUP), 2021-05-07)
Objective: To summarize existing literature on the mental health impact of the Flint Water Crisis.
Methods: In March 2020, we searched 5 databases for literature exploring the psychological consequences of the crisis. ...
Functionally informed fine-mapping and polygenic localization of complex trait heritability
(Springer Science and Business Media LLC, 2020-11-16)
Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-mapping accuracy by leveraging functional annotations across the entire ...
Optimal dietary patterns for prevention of chronic disease
(Springer Science and Business Media LLC, 2023-03)
Multiple dietary patterns have been associated with different diseases; however, their comparability to improve overall health is yet to be determined. In 205,852 healthcare professionals from three US cohorts followed ...
Corruption and disasters in the built environment: a literature review
(Wiley, 2022-07-11)
This paper presents the findings of a review of academic literature concerning the degree to which corruption worsens naturally-triggered disasters in the built environment. The research employed a ‘systematic literature ...
Modeling the Comparative Impact of Individual Quarantine vs. Active Monitoring of Contacts for the Mitigation of COVID-19
(2020-03-08)
Individual quarantine and active monitoring of contacts are core disease control strategies, particularly for emerging infectious diseases such as Coronavirus Disease 2019 (COVID-19). To estimate the comparative efficacy ...
Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination
(2021)
When vaccines are in limited supply, expanding the number of people who receive some vaccine can reduce disease and mortality compared to concentrating vaccines in a subset of the population. A corollary of such dose-sparing ...
Population-scale Longitudinal Mapping of COVID-19 Symptoms, Behaviour, and Testing
(Nature Human Behaviour, 2020-08-26)
Despite the widespread implementation of public health measures, COVID-19 continues to spread in the United States. To facilitate an agile response to the pandemic, we developed How We Feel, a web and mobile application ...