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A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research
(National Institute of Environmental Health Sciences, 2006)
Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better ...
Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
(BioMed Central, 2001)
The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 ...
Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
(Public Library of Science, 2009)
Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in ...
The genomic origins of asthma
(BMJ, 2014)
Lung function tracks from the earliest age that it can be reliably measured. Genome wide association studies (GWAS) suggest that most variants identified for common complex traits are both regulatory in function and active ...
Expression analysis of asthma candidate genes during human and murine lung development
(Springer Science + Business Media, 2011)
Background: Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung ...
Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D
(Elsevier BV, 2012)
Background— The adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been associated with decreased ...
Ambient air pollution, lung function, and airway responsiveness in asthmatic children
(Elsevier BV, 2016)
Background:
Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthma are lacking.
Objective:
To investigate pollution effects in ...
Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving
(Future Medicine Ltd, 2015)
Aim: To identify the clinical and economic circumstances under which a pharmacogenomic test that predicts response to inhaled corticosteroids might be a cost-effective option for individuals with asthma.
Materials & ...
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease
(Elsevier BV, 2014)
Background:
TH2-dependent diseases vary in severity according to genotype, but relevant gene polymorphisms remain largely unknown. The integrin CD11a is a critical determinant of allergic responses, and allelic variants ...
Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma
(Wiley-Blackwell, 2011)
Background— Distinct receptors likely exist for leukotriene(LT)E4, a potent mediator of airway inflammation. Purinergic receptor P2Y12 is needed for LTE4-induced airways inflammation, and P2Y12 antagonism attenuates house ...