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Bacterial Vaccines and Serotype Replacement: Lessons from Haemophilus influenzae and Prospects for Streptococcus pneumoniae
(Centers for Disease Control and Prevention (CDC), 1999)
Conjugate vaccines have reduced the incidence of invasive disease caused by Haemophilus influenzae, type b (Hib), in industrialized countries and may be highly effective against Streptococcus pneumoniae. However, the ...
Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast
(Proceedings of the National Academy of Sciences, 1997)
Sequence divergence acts as a potent barrier to homologous recombination; much of this barrier derives from an antirecombination activity exerted by mismatch repair proteins. An inverted repeat assay system with recombination ...
Vaccination against colonizing bacteria with multiple serotypes
(Proceedings of the National Academy of Sciences, 1997)
Conjugate vaccines protect vaccinated individuals against both disease from and nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae. Protection is specific to the capsular serotype(s) included ...