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Antiviral Resistance and the Control of Pandemic Influenza
(Public Library of Science, 2007)
Background: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest ...
Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
(Public Library of Science, 2009)
There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these ...
The Severity of Pandemic H1N1 Influenza in the United States, from April to July 2009: A Bayesian Analysis
(Public Library of Science, 2009)
Background: Accurate measures of the severity of pandemic (H1N1) 2009 influenza (pH1N1) are needed to assess the likely impact of an anticipated resurgence in the autumn in the Northern Hemisphere. Severity has been difficult ...
Hedging against Antiviral Resistance during the Next Influenza Pandemic Using Small Stockpiles of an Alternative Chemotherapy
(Public Library of Science, 2009)
Background: The effectiveness of single-drug antiviral interventions to reduce morbidity and mortality during the next influenza pandemic will be substantially weakened if transmissible strains emerge which are resistant ...
Quantifying Child Mortality Reductions Related to Measles Vaccination
(Public Library of Science, 2010)
Background: This study characterizes the historical relationship between coverage of measles containing vaccines (MCV) and mortality in children under 5 years, with a view toward ongoing global efforts to reduce child ...
Absolute Humidity and the Seasonal Onset of Influenza in the Continental United States
(Public Library of Science, 2010)
Much of the observed wintertime increase of mortality in temperate regions is attributed to seasonal influenza. A recent reanalysis of laboratory experiments indicates that absolute humidity strongly modulates the airborne ...
Studies Needed to Address Public Health Challenges of the 2009 H1N1 Influenza Pandemic: Insights from Modeling
(Public Library of Science, 2010)
In light of the 2009 influenza pandemic and potential future pandemics, Maria Van Kerkhove and colleagues anticipate six public health challenges and the data needed to support sound public health decision making.