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Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...
Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...
Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2006)
Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ...
Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline
(National Institute of Environmental Health Sciences, 2007)
Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ...
Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...