Now showing items 1-5 of 5
Blood Epigenetic Age may Predict Cancer Incidence and Mortality
Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...
Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study
Background: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based ...
Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment
(BioMed Central, 2014)
Background: Traffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups ...
DNA methylation-based measures of biological age: meta-analysis predicting time to death
(Impact Journals LLC, 2016)
Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...