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Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
(Public Library of Science, 2016)
Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a ...
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure
(Public Library of Science, 2016)
Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular ...
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease
(Public Library of Science, 2016)
We performed an exome-wide association analysis in 1393 late-onset Alzheimer’s disease (LOAD) cases and 8141 controls from the CHARGE consortium. We found that a rare variant (P155L) in TM2D3 was enriched in Icelanders ...