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Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...
Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...
Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
(National Institute of Environmental Health Sciences, 2007)
Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ...
Night heart rate variability and particulate exposures among boilermaker construction workers
(National Institute of Environmental Health Sciences, 2007)
Background: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate ...
Chimney Stove Intervention to Reduce Long-term Wood Smoke Exposure Lowers Blood Pressure among Guatemalan Women
(National Institute of Environmental Health Sciences, 2007)
Background and Objective: RESPIRE, a randomized trial of an improved cookstove, was conducted in Guatemala to assess health effects of long-term reductions in wood smoke exposure. Given the evidence that ambient particles ...
Mortality Risk Associated with Short-Term Exposure to Traffic Particles and Sulfates
(National Institute of Environmental Health Sciences, 2007)
Background: Many studies have shown that airborne particles are associated with increased risk of death, but attention has more recently focused on the differential toxicity of particles from different sources. Geographic ...
Short-term Effects of Carbon Monoxide on Mortality: An Analysis within the APHEA Project
(National Institute of Environmental Health Sciences, 2007)
Objectives: We investigated the short-term effects of carbon monoxide on total and cardiovascular mortality in 19 European cities participating in the APHEA-2 (Air Pollution and Health: A European Approach) project. Methods: ...
Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline
(National Institute of Environmental Health Sciences, 2007)
Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ...
Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip
(National Institute of Environmental Health Sciences, 2007)
Objectives: Airborne particles have been linked to pulmonary oxidative stress and inflammation. Because these effects may be particularly great for traffic-related particles, we examined associations between particle ...