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Genome-Wide Association Studies of Multiple Keratinocyte Cancers
(Public Library of Science, 2017)
There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly ...
Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials
(Public Library of Science, 2017)
Aims This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation. Methods and Results: Intra-tracheal administration of NM: gold nanoparticles (AuNPs) of 5-, 60- and 250-nm diameter; ...
Biomarker-Defined Subsets of Common Diseases: Policy and Economic Implications of Orphan Drug Act Coverage
(Public Library of Science, 2017)
Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States.