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Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
(Public Library of Science, 2013)
Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. ...
Novel genetic markers improve measures of atrial fibrillation risk prediction
(Oxford University Press, 2013)
Aims Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown. Methods and results We derived and validated a novel AF risk prediction ...
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
(Public Library of Science, 2012)
Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, ...