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The Effect of Dose and Timing of Dose on the Association between Airborne Particles and Survival
(2008)
BACKGROUND: Understanding the shape of the concentration–response curve for particles is important
for public health, and lack of such understanding was recently cited by U.S. Environmental
Protection Agency (EPA) as a ...
Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study
(BioMed Central, 2010)
Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ...
Decreased PM10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53, p21, and CCND1 Modify This Effect
(National Institute of Environmental Health Sciences, 2009)
Background: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is ...
Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
Pesticide spraying for West Nile virus control and emergency department asthma visits in New York City, 2000
(National Institue of Environmental Health Sciences, 2004)
Pyrethroid pesticides were applied via ground spraying to residential neighborhoods in New York City during July–September 2000 to control mosquito vectors of West Nile virus (WNV). Case reports link pyrethroid exposure ...
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water.
(2002)
There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ...
Association of Cumulative Lead Exposure with Parkinson’s Disease
(National Institute of Environmental Health Sciences, 2010)
Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...
Is There Adaptation in the Ozone Mortality Relationship: A Multi-City Case-Crossover Analysis
(BioMed Central, 2008)
Background: Ozone has been associated with daily mortality, mainly in the summer period. Despite the ample literature on adaptation of inflammatory and pulmonary responses to ozone, and the link, in cohort studies, between ...
Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study
(National Institue of Environmental Health Sciences, 2004)
In this prospective study, we examined changes in renal function during 6 years of follow-up in relation to baseline lead levels, diabetes, and hypertension among 448 middle-age and elderly men, a subsample of the Normative ...
Glutathione S-Transferase Polymorphisms, Passive Smoking, Obesity, and Heart Rate Variability in Nonsmokers
(National Institute of Environmental Health Sciences, 2008)
Background: Disturbances of heart rate variability (HRV) may represent one pathway by which second-hand smoke (SHS) and air pollutants affect cardiovascular morbidity and mortality. The mechanisms are poorly understood. ...