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Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC
(Public Library of Science, 2012)
The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer and nutrition. This study has served as a ...
Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
(Public Library of Science, 2012)
Background: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined ...
Social Inequalities and Mortality in Europe – Results from a Large Multi-National Cohort
(Public Library of Science, 2012)
Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social ...
Prognostic Significance of Elevated Cardiac Troponin-T Levels in Acute Respiratory Distress Syndrome Patients
(Public Library of Science, 2012)
Background: Elevated levels of biochemical markers of myocardial necrosis have been associated with worsened outcomes in Acute Respiratory Distress Syndrome (ARDS), but there are few prospective data on this relationship. ...
Blood Donation and Colorectal Cancer Incidence and Mortality in Men
(Public Library of Science, 2012)
Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...
Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women
(Public Library of Science, 2012)
Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker ...
A Comparison of Three Methods to Measure Asthma in Epidemiologic Studies: Results from the Danish National Birth Cohort
(Public Library of Science, 2012)
Asthma is a heterogeneous outcome and how the condition should be measured to best capture clinically relevant disease in epidemiologic studies remains unclear. We compared three methods of measuring asthma in the Danish ...
Development and Validation of a Social Capital Questionnaire for Adolescent Students (SCQ-AS)
(Public Library of Science, 2014)
Objectives: Social capital has been studied due to its contextual influence on health. However, no specific assessment tool has been developed and validated for the measurement of social capital among 12-year-old adolescent ...
Whole Blood Gene Expression and Atrial Fibrillation: The Framingham Heart Study
(Public Library of Science, 2014)
Background: Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF. ...
Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study
(Public Library of Science, 2014)
Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily ...