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Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...
Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...
Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women
(National Institute of Environmental Health Sciences, 2008)
Background: Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. Objective: We examined biomarkers of lead ...
Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study.
(2004)
Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...
Effect of Calcium Supplementation on Blood Lead Levels in Pregnancy: A Randomized Placebo-Controlled Trial
(National Institute of Environmental Health Sciences, 2008)
Background: Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of maternal bone lead and/or intestinal ...
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)
Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
(National Institute of Environmental Health Sciences, 2006)
Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. Objective: We ...
Effect of breast milk lead on infant blood lead levels at 1 month of age
(National Institue of Environmental Health Sciences, 2004)
Nursing infants may be exposed to lead from breast milk, but relatively few data exist with which to evaluate and quantify this relationship. This route of exposure constitutes a potential infant hazard from mothers with ...
Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
(National Institute of Environmental Health Sciences, 2008)
Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...
Variants in iron metabolism genes predict higher blood lead levels in young children
(National Institute of Environmental Health Sciences, 2008)
Background: Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children. Objective: We examined the ...