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Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...
Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)
Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...
Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study.
(2004)
Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...
Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter
(National Institute of Environmental Health Sciences, 2009)
Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ...
Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study
(National Institute of Environmental Health Sciences, 2009)
Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...
Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
(National Institute of Environmental Health Sciences, 2008)
Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...
Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
(National Institute of Environmental Health Sciences, 2007)
Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ...
Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study
(National Institute of Environmental Health Sciences, 2006)
Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ...
Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline
(National Institute of Environmental Health Sciences, 2007)
Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ...
A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study.
(2003)
In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function ...