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Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
(National Institute of Environmental Health Sciences, 2010)
Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)
Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes
(National Institute of Environmental Health Sciences, 2010)
Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...
Effect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactions
(BioMed Central, 2010)
Background: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ...
Modifiers of Short-term Effects of Ozone on Mortality in Eastern Massachusetts: A Case-crossover Analysis at Individual Level
(BioMed Central, 2010)
Background: Substantial epidemiological studies demonstrate associations between exposure to ambient ozone and mortality. A few studies simply examine the modification of this ozone effect by individual characteristics and ...
Exposure to Metal-rich Particulate Matter Modifies the Expression of Candidate Micrornas in Peripheral Blood Leukocytes
(National Institute of Environmental Health Sciences, 2010)
Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. MicroRNAs (miRNAs) are ...
Associations between outdoor temperature and markers of inflammation: a cohort study
(BioMed Central, 2010)
Background: Associations between ambient temperature and cardiovascular mortality are well established. This study investigated whether inflammation could be part of the mechanism leading to temperature-related cardiovascular ...
Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study
(BioMed Central, 2010)
Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ...
Association of Cumulative Lead Exposure with Parkinson’s Disease
(National Institute of Environmental Health Sciences, 2010)
Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...