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Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)
Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
Lead Concentrations in Relation to Multiple Biomarkers of Cardiovascular Disease: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2012)
Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between ...
Association of Cumulative Lead Exposure with Parkinson’s Disease
(National Institute of Environmental Health Sciences, 2010)
Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...
Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study
(National Institute of Environmental Health Sciences, 2012)
Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...
Associations of Early Childhood Manganese and Lead Coexposure with Neurodevelopment
(National Institute of Environmental Health Sciences, 2011)
Background: Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals. Objectives: We prospectively studied manganese–lead ...