Now showing items 1-3 of 6209

    • MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212 

      Rosa, Valentina La; Poce, Giovanna; Canseco, Julio Ortiz; Buroni, Silvia; Pasca, Maria Rosalia; Biava, Mariangela; Raju, Ravikiran M.; Porretta, Giulio Cesare; Alfonso, Salvatore; Battilocchio, Claudio; Javid, Babak; Sorrentino, Flavia; Ioerger, Thomas R.; Sacchettini, James C.; Manetti, Fabrizio; Botta, Maurizio; Logu, Alessandro De; Rubin, Eric J.; Rossi, Edda De (American Society for Microbiology, 2012)
      The 1,5-diarylpyrrole derivative BM212 was previously shown to be active against multidrug-resistant clinical isolates and Mycobacterium tuberculosis residing within macrophages as well as against Mycobacterium avium and ...
    • Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase 

      Kim, Jee-Hyun; Wei, Jun-Rong; Wallach, Joshua B.; Robbins, Rebekkah S.; Rubin, Eric J.; Schnappinger, Dirk (Oxford University Press, 2011)
      Using a component of the Escherichia coli protein degradation machinery, we have established a system to regulate protein stability in mycobacteria. A protein tag derived from the E. coli SsrA degradation signal did not ...
    • Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance 

      Javid, Babak; Sorrentino, Flavia; Toosky, Melody; Zheng, Wen; Pinkham, Jessica T.; Jain, Nina; Pan, Miaomiao; Deighan, Padraig; Rubin, Eric J. (National Academy of Sciences, 2014)
      Errors are inherent in all biological systems. Errors in protein translation are particularly frequent giving rise to a collection of protein quasi-species, the diversity of which will vary according to the error rate. As ...