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dc.contributor.authorGarshick, Eric
dc.contributor.authorLaden, Francine
dc.contributor.authorHart, Jaime Elizabeth
dc.contributor.authorRosner, Bernard Alfred
dc.contributor.authorSmith, Thomas J.
dc.contributor.authorDockery, Douglas W.
dc.contributor.authorSpeizer, Frank Erwin
dc.date.accessioned2010-10-05T14:50:43Z
dc.date.issued2004
dc.identifier.citationGarshick, Eric, Francine Laden, Jaime E. Hart, Bernard Rosner, Thomas J. Smith, Douglas W. Dockery, and Frank E. Speizer. 2004. Lung Cancer in Railroad Workers Exposed to Diesel Exhaust. Environmental Health Perspectives 112(15): 1539-1543.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4457603
dc.description.abstractDiesel exhaust has been suspected to be a lung carcinogen. The assessment of this lung cancer risk has been limited by lack of studies of exposed workers followed for many years. In this study, we assessed lung cancer mortality in 54,973 U.S. railroad workers between 1959 and 1996 (38 years). By 1959, the U.S. railroad industry had largely converted from coal-fired to diesel-powered locomotives. We obtained work histories from the U.S. Railroad Retirement Board, and ascertained mortality using Railroad Retirement Board, Social Security, and Health Care Financing Administration records. Cause of death was obtained from the National Death Index and death certificates. There were 43,593 total deaths including 4,351 lung cancer deaths. Adjusting for a healthy worker survivor effect and age, railroad workers in jobs associated with operating trains had a relative risk of lung cancer mortality of 1.40 (95% confidence interval, 1.30–1.51). Lung cancer mortality did not increase with increasing years of work in these jobs. Lung cancer mortality was elevated in jobs associated with work on trains powered by diesel locomotives. Although a contribution from exposure to coal combustion products before 1959 cannot be excluded, these results suggest that exposure to diesel exhaust contributed to lung cancer mortality in this cohort.en_US
dc.description.sponsorshipStatisticsen_US
dc.language.isoen_USen_US
dc.publisherNational Institue of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.7195en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247618/pdf/en_US
dash.licenseLAA
dc.subjectdiesel exhausten_US
dc.subjectlung canceren_US
dc.subjectoccupational exposureen_US
dc.titleLung Cancer in Railroad Workers Exposed to Diesel Exhausten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorRosner, Bernard Alfred
dc.date.available2010-10-05T14:50:43Z
dc.identifier.doi10.1289/ehp.7195*
dash.contributor.affiliatedRosner, Bernard
dash.contributor.affiliatedSpeizer, Frank
dash.contributor.affiliatedGarshick, Eric
dash.contributor.affiliatedDockery, Douglas
dash.contributor.affiliatedSmith, Thomas
dash.contributor.affiliatedHart, Jaime
dash.contributor.affiliatedLaden, Francine
dc.identifier.orcid0000-0002-2813-2174


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