Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
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CitationWang, Qiu, and Stuart L. Schreiber. 2009. Copper-mediated amidation of heterocyclic and aromatic C−H bonds. Organic Letters 11(22): 5178-5180.
AbstractA copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
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