Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity

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Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity

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Title: Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity
Author: Krienen, Fenna Marie; Buckner, Randy Lee

Note: Order does not necessarily reflect citation order of authors.

Citation: Krienen, Fenna M., and Randy L. Buckner. 2009. Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity. Cerebral Cortex 19(10): 2485-2497.
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Abstract: Multiple, segregated fronto-cerebellar circuits have been characterized in nonhuman primates using transneuronal tracing techniques including those that target prefrontal areas. Here, we used functional connectivity MRI (fcMRI) in humans (n = 40) to identify 4 topographically distinct fronto-cerebellar circuits that target 1) motor cortex, 2) dorsolateral prefrontal cortex, 3) medial prefrontal cortex, and 4) anterior prefrontal cortex. All 4 circuits were replicated and dissociated in an independent data set (n = 40). Direct comparison of right- and left-seeded frontal regions revealed contralateral lateralization in the cerebellum for each of the segregated circuits. The presence of circuits that involve prefrontal regions confirms that the cerebellum participates in networks important to cognition including a specific fronto-cerebellar circuit that interacts with the default network. Overall, the extent of the cerebellum associated with prefrontal cortex included a large portion of the posterior hemispheres consistent with a prominent role of the cerebellum in nonmotor functions. We conclude by providing a provisional map of the topography of the cerebellum based on functional correlations with the frontal cortex.
Published Version: doi:10.1093/cercor/bhp135
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742600/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4459223
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