Reconstruction of the Neuromuscular Junction Connectome

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Reconstruction of the Neuromuscular Junction Connectome

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Title: Reconstruction of the Neuromuscular Junction Connectome
Author: Srinivasan, Ranga; Wong, Stephen T.C.; Li, Qing; Lichtman, Jeff; Lu, Ju; Zhou, Xiaobo

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Citation: Srinivasan, Ranga, Qing Li, Xiaobo Zhou, Ju Lu, Jeff Lichtman, and Stephen T. C. Wong. 2010. Reconstruction of the neuromuscular junction connectome. Bioinformatics 26(12): i64-i70.
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Abstract: Motivation: Unraveling the structure and behavior of the brain and central nervous system (CNS) has always been a major goal of neuroscience. Understanding the wiring diagrams of the neuromuscular junction connectomes (full connectivity of nervous system neuronal components) is a starting point for this, as it helps in the study of the organizational and developmental properties of the mammalian CNS. The phenomenon of synapse elimination during developmental stages of the neuronal circuitry is such an example. Due to the organizational specificity of the axons in the connectomes, it becomes important to label and extract individual axons for morphological analysis. Features such as axonal trajectories, their branching patterns, geometric information, the spatial relations of groups of axons, etc. are of great interests for neurobiologists in the study of wiring diagrams. However, due to the complexity of spatial structure of the axons, automatically tracking and reconstructing them from microscopy images in 3D is an unresolved problem. In this article, AxonTracker-3D, an interactive 3D axon tracking and labeling tool is built to obtain quantitative information by reconstruction of the axonal structures in the entire innervation field. The ease of use along with accuracy of results makes AxonTracker-3D an attractive tool to obtain valuable quantitative information from axon datasets. Availability: The software is freely available for download at Contact:
Published Version: doi:10.1093/bioinformatics/btq179
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Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at
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