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dc.contributor.authorWalsh, Emily
dc.contributor.authorSchaffner, Steve F
dc.contributor.authorVarilly, Patrick
dc.contributor.authorFry, Ben
dc.contributor.authorHutcheson, Holli B
dc.contributor.authorCullen, Mike
dc.contributor.authorMikkelsen, Tarjei S
dc.contributor.authorRoy, Jessica
dc.contributor.authorPatterson, Nick
dc.contributor.authorSabeti, Pardis Christine
dc.contributor.authorCooper, Richard
dc.contributor.authorReich, David Emil
dc.contributor.authorAltshuler, David Matthew
dc.contributor.authorO'Brien, Stephen James
dc.contributor.authorLander, Eric Steven
dc.date.accessioned2010-10-07T15:47:17Z
dc.date.issued2005
dc.identifier.citationSabeti, Pardis C., Emily Walsh, Steve F. Schaffner, Patrik Varilly, Ben Fry, Holli B. Hutcheson, Mike Cullen, et al. 2005. The Case for Selection at Δ. PLoS Biology 3(11): e378.en_US
dc.identifier.issn1544-9173en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4460864
dc.description.abstractThe C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to its present high frequency (5%–14%) in Europe as a result of strong positive selection, perhaps by such selective agents as the bubonic plague or smallpox during the Middle Ages. This hypothesis was based on several lines of evidence, including the absence of the allele outside of Europe and long-range linkage disequilibrium at the locus. We reevaluated this evidence with the benefit of much denser genetic maps and extensive control data. We find that the pattern of genetic variation at CCR5-Δ32 does not stand out as exceptional relative to other loci across the genome. Moreover using newer genetic maps, we estimated that the CCR5-Δ32 allele is likely to have arisen more than 5,000 y ago. While such results can not rule out the possibility that some selection may have occurred at C-C chemokine receptor 5 (CCR5), they imply that the pattern of genetic variation seen atCCR5-Δ32 is consistent with neutral evolution. More broadly, the results have general implications for the design of future studies to detect the signs of positive selection in the human genome.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pbio.0030378en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1275522/pdf/en_US
dash.licenseLAA
dc.subjectbioinformaticsen_US
dc.subjectcomputational biologyen_US
dc.subjectevolutionen_US
dc.subjectgeneticsen_US
dc.subjectgenomicsen_US
dc.subjectgene therapyen_US
dc.subjectinfectious diseasesen_US
dc.subjectHIVen_US
dc.subjectAIDSen_US
dc.subjecthomo (human)en_US
dc.titleThe Case for Selection at CCR5-Δ32en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Biologyen_US
dash.depositing.authorSabeti, Pardis Christine
dc.date.available2010-10-07T15:47:17Z
dc.identifier.doi10.1371/journal.pbio.0030378*
dash.authorsorderedfalse
dash.contributor.affiliatedO'Brien, Stephen
dash.contributor.affiliatedAltshuler, David
dash.contributor.affiliatedReich, David
dash.contributor.affiliatedSabeti, Pardis
dash.contributor.affiliatedLander, Eric


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