Model-Based Analysis of Two-Color Arrays (MA2C)

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Model-Based Analysis of Two-Color Arrays (MA2C)

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Title: Model-Based Analysis of Two-Color Arrays (MA2C)
Author: Zhu, Xiaopeng; Zhang, Xinmin; Chen, Runsheng; Manrai, Arjun Kumar; Song, Jun S; Johnson, W. Evan; Li, Wei; Liu, Xiaole Shirley; Liu, Jun

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Citation: Song, Jun S., W. Evan Johnson, Xiaopeng Zhu, Xinmin Zhang, Wei Li, Arjun K. Manrai, Jun S. Liu, Runsheng Chen, and X. Shirley Liu. 2007. Model-based analysis of two-color arrays (MA2C). Genome Biology 8(8): R178.
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Abstract: A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.
Published Version: doi:10.1186/gb-2007-8-8-r178
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