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dc.contributor.authorBininda-Emonds, Olaf RP
dc.contributor.authorJeffery, Jonathan E
dc.contributor.authorSánchez-Villagra, Marcelo R
dc.contributor.authorColbert, Matthew
dc.contributor.authorPieau, Claude
dc.contributor.authorSelwood, Lynne
dc.contributor.authorten Cate, Carel
dc.contributor.authorRaynaud, Albert
dc.contributor.authorOsabutey, Casmile K
dc.contributor.authorHanken, James
dc.contributor.authorRichardson, Michael K.
dc.date.accessioned2010-10-07T17:20:24Z
dc.date.issued2007
dc.identifier.citationBininda-Emonds, Olaf R.P., Jonathan E. Jeffery, Marcelo R. Sánchez-Villagra, James Hanken, Matthew Colbert, Claude Pieau, Lynne Selwood, et al. 2007. Forelimb-hindlimb developmental timing changes across tetrapod phylogeny. BMC Evolutionary Biology 7:182.en_US
dc.identifier.issn1471-2148en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4461122
dc.description.abstractBackground: Tetrapods exhibit great diversity in limb structures among species and also between forelimbs and hindlimbs within species, diversity which frequently correlates with locomotor modes and life history. We aim to examine the potential relation of changes in developmental timing (heterochrony) to the origin of limb morphological diversity in an explicit comparative and quantitative framework. In particular, we studied the relative time sequence of development of the forelimbs versus the hindlimbs in 138 embryos of 14 tetrapod species spanning a diverse taxonomic, ecomorphological and life-history breadth. Whole-mounts and histological sections were used to code the appearance of 10 developmental events comprising landmarks of development from the early bud stage to late chondrogenesis in the forelimb and the corresponding serial homologues in the hindlimb. Results: An overall pattern of change across tetrapods can be discerned and appears to be relatively clade-specific. In the primitive condition, as seen in Chondrichthyes and Osteichthyes, the forelimb/pectoral fin develops earlier than the hindlimb/pelvic fin. This pattern is either retained or re-evolved in eulipotyphlan insectivores (= shrews, moles, hedgehogs, and solenodons) and taken to its extreme in marsupials. Although exceptions are known, the two anurans we examined reversed the pattern and displayed a significant advance in hindlimb development. All other species examined, including a bat with its greatly enlarged forelimbs modified as wings in the adult, showed near synchrony in the development of the fore and hindlimbs. Conclusion: Major heterochronic changes in early limb development and chondrogenesis were absent within major clades except Lissamphibia, and their presence across vertebrate phylogeny are not easily correlated with adaptive phenomena related to morphological differences in the adult fore- and hindlimbs. The apparently conservative nature of this trait means that changes in chondrogenetic patterns may serve as useful phylogenetic characters at higher taxonomic levels in tetrapods. Our results highlight the more important role generally played by allometric heterochrony in this instance to shape adult morphology.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2148-7-182en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194785/pdf/en_US
dash.licenseLAA
dc.titleForelimb-Hindlimb Developmental Timing Changes across Tetrapod Phylogenyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Evolutionary Biologyen_US
dash.depositing.authorHanken, James
dc.date.available2010-10-07T17:20:24Z
dc.identifier.doi10.1186/1471-2148-7-182*
dash.authorsorderedfalse
dash.contributor.affiliatedHanken, James


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