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dc.contributor.authorMar, Jessica Cara
dc.contributor.authorRubio, Renee
dc.contributor.authorQuackenbush, John
dc.date.accessioned2010-11-01T19:12:05Z
dc.date.issued2006
dc.identifier.citationMar, Jessica C., Renee Rubio, and John Quackenbush. 2006. Inferring steady state single-cell gene expression distributions from analysis of mesoscopic samples. Genome Biology 7(12): R119.en_US
dc.identifier.issn1465-6906en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4515107
dc.description.abstractBackground: A great deal of interest has been generated by systems biology approaches that attempt to develop quantitative, predictive models of cellular processes. However, the starting point for all cellular gene expression, the transcription of RNA, has not been described and measured in a population of living cells. Results: Here we present a simple model for transcript levels based on Poisson statistics and provide supporting experimental evidence for genes known to be expressed at high, moderate, and low levels. Conclusion: Although the model describes a microscopic process occurring at the level of an individual cell, the supporting data we provide uses a small number of cells where the echoes of the underlying stochastic processes can be seen. Not only do these data confirm our model, but this general strategy opens up a potential new approach, Mesoscopic Biology, that can be used to assess the natural variability of processes occurring at the cellular level in biological systems.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/gb-2006-7-12-r119en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794432/pdf/en_US
dash.licenseLAA
dc.titleInferring steady state single-cell gene expression distributions from analysis of mesoscopic samplesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Biologyen_US
dash.depositing.authorMar, Jessica Cara
dc.date.available2010-11-01T19:12:05Z
dash.affiliation.otherSPH^Student Stipendsen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dc.identifier.doi10.1186/gb-2006-7-12-r119*
dash.contributor.affiliatedMar, Jessica Cara
dash.contributor.affiliatedQuackenbush, John
dc.identifier.orcid0000-0002-2702-5879


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