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dc.contributor.authorGurgueira, Sonia A
dc.contributor.authorLawrence, Joy E.
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorMurthy, G G Krishna
dc.contributor.authorGonzález-Flecha, Beatriz
dc.date.accessioned2010-11-04T20:38:18Z
dc.date.issued2002
dc.identifier.citationGurgueira, Sonia A., Joy Lawrence, Brent Coull, G. G. Krishna Murthy, and Beatriz González-Flecha. 2002. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environmental Health Perspectives 110(8): 749-755.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4522597
dc.description.abstractIn vitro studies suggest that reactive oxygen species contribute to the cardiopulmonary toxicity of particulate air pollution. To evaluate the ability of particulate air pollution to promote oxidative stress and tissue damage in vivo, we studied a rat model of short-term exposure to concentrated ambient particles (CAPs). We exposed adult Sprague-Dawley rats to either CAPs aerosols (group 1; average CAPs mass concentration, 300 +/- 60 micro g/m3) or filtered air (sham controls) for periods of 1-5 hr. Rats breathing CAPs aerosols for 5 hr showed significant oxidative stress, determined as in situ chemiluminescence in the lung [group 1, 41 +/- 4; sham, 24 +/- 1 counts per second (cps)/cm2] and heart (group 1, 45 +/- 4; sham, 24 +/- 2 cps/cm2) but not liver (group 1, 10 +/- 3; sham, 13 +/- 3 cps/cm2). Increases in oxidant levels were also triggered by highly toxic residual oil fly ash particles (lung chemiluminescence, 90 +/- 10 cps/cm2; heart chemiluminescence, 50 +/- 3 cps/cm2) but not by particle-free air or by inert carbon black aerosols (control particles). Increases in chemiluminescence showed strong associations with the CAPs content of iron, manganese, copper, and zinc in the lung and with Fe, aluminum, silicon, and titanium in the heart. The oxidant stress imposed by 5-hr exposure to CAPs was associated with slight but significant increases in the lung and heart water content (approximately 5% in both tissues, p < 0.05) and with increased serum levels of lactate dehydrogenase (approximately 80%), indicating mild damage to both tissues. Strikingly, CAPs inhalation also led to tissue-specific increases in the activities of the antioxidant enzymes superoxide dismutase and catalase, suggesting that episodes of increased particulate air pollution not only have potential for oxidant injurious effects but may also trigger adaptive responses.en_US
dc.language.isoen_USen_US
dc.publisherThe National Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.02110749en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240944/pdf/en_US
dash.licenseLAA
dc.subjectCAPsen_US
dc.subjectconcentrated ambient particlesen_US
dc.subjectoxidative stressen_US
dc.subjectparticulate air pollutionen_US
dc.subjectreactive oxygen speciesen_US
dc.titleRapid Increases in the Steady-state Concentration of Reactive Oxygen Species in the Lungs and Heart After Particulate Air Pollution Inhalation.en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorCoull, Brent Andrew
dc.date.available2010-11-04T20:38:18Z
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dc.identifier.doi10.1289/ehp.02110749*
dash.contributor.affiliatedLawrence, Joy
dash.contributor.affiliatedCoull, Brent


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