New Insights into the Functions and Regulation of the Transcriptional Corepressors SMRT and N-CoR

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New Insights into the Functions and Regulation of the Transcriptional Corepressors SMRT and N-CoR

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Title: New Insights into the Functions and Regulation of the Transcriptional Corepressors SMRT and N-CoR
Author: Kao, Hung-Ying; Stanya, Kristopher J

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Citation: Stanya, Kristopher J., and Hung-Ying Kao. 2009. New insights into the functions and Regulation of the Transcriptional Corepressors SMRT and N-CoR. Cell Division 4:7.
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Abstract: Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.
Published Version: doi:10.1186/1747-1028-4-7
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678994/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4551791
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