Towards an Integrated Model for Breast Cancer Etiology: The Crucial Role of the Number of Mammary Tissue-Specific Stem Cells

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Towards an Integrated Model for Breast Cancer Etiology: The Crucial Role of the Number of Mammary Tissue-Specific Stem Cells

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Title: Towards an Integrated Model for Breast Cancer Etiology: The Crucial Role of the Number of Mammary Tissue-Specific Stem Cells
Author: Trichopoulos, Dimitrios; Lagiou, Pagona; Adami, Hans-Olov

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Citation: Trichopoulos, Dimitrios, Pagona Lagiou, and Hans-Olov Adami. 2005. Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells. Breast Cancer Research 7(1): 13-17.
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Abstract: Perinatal events and conditions, notably birth weight, are associated with breast cancer risk in offspring, and correlates of mammary gland mass are predictors of breast cancer risk. These findings may be interpreted as indicating that high levels of estrogens and components of the insulin-like growth factor system during pregnancy favour the generation of mammary tissue-specific stem cells, and that the number of these cells, which is positively associated with mammary gland mass, is an important determinant of breast cancer risk. Perinatal events and conditions may also affect risk for other malignancies, but the evidence in the case of breast cancer is prominent, possibly because estrogens and the insulin-like growth factor system are both involved in breast cancer etiology and affect birth weight.
Published Version: doi:10.1186/bcr966
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064112/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553304
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