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dc.contributor.authorOjosnegros, Samuel
dc.contributor.authorBeerenwinkel, Niko
dc.contributor.authorAntal, Tibor
dc.contributor.authorNowak, Martin A.
dc.contributor.authorEscarmis, Christina
dc.contributor.authorDomingo, Esteban
dc.date.accessioned2010-11-15T20:31:44Z
dc.date.issued2010
dc.identifier.citationOjosnegros Samuel, Niko Beerenwinkel, Tibor Antal, Martin A. Nowak, Christina Escarmis,and Esteban Domingo. 2010. Competition-colonization dynamics in an RNA virus. Proceedings of the National Academy of Sciences of the United States of America 107(5): 2108-2112.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4554747
dc.description.abstractDuring replication, RNA viruses rapidly generate diverse mutant progeny which differ in their ability to kill host cells. We report that the progeny of a single RNA viral genome diversified during hundreds of passages in cell culture and self-organized into two genetically distinct subpopulations that exhibited the competition-colonization dynamics previously recognized in many classical ecological systems. Viral colonizers alone were more efficient in killing cells than competitors in culture. In cells coinfected with both competitors and colonizers, viral interference resulted in reduced cell killing, and competitors replaced colonizers. Mathematical modeling of this coinfection dynamics predicted selection to be density dependent, which was confirmed experimentally. Thus, as is known for other ecological systems, biodiversity and even cell killing of virus populations can be shaped by a tradeoff between competition and colonization. Our results suggest a model for the evolution of virulence in viruses based on internal interactions within mutant spectra of viral quasispecies.en_US
dc.description.sponsorshipMathematicsen_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.0909787107en_US
dc.relation.hasversionhttp://www.ped.fas.harvard.edu/people/faculty/all_publications.html#2010en_US
dash.licenseLAA
dc.subjectevolutionen_US
dc.subjectquasispeciesen_US
dc.subjectself-organizationen_US
dc.subjectvirulenceen_US
dc.titleCompetition-Colonization Dynamics in an RNA Virusen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dash.depositing.authorNowak, Martin A.
dc.date.available2014-10-22T07:30:40Z
dc.identifier.doi10.1073/pnas.0909787107*
workflow.legacycommentsBrightening on 10/21/2014, per new OSC interpretation of PNAS policy.
dash.contributor.affiliatedAntal, Tibor
dash.contributor.affiliatedNowak, Martin


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