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dc.contributor.authorLingappa, Jairam R.
dc.contributor.authorKahle, Erin
dc.contributor.authorMugo, Nelly
dc.contributor.authorMujugira, Andrew
dc.contributor.authorMagaret, Amalia
dc.contributor.authorBaeten, Jared
dc.contributor.authorBukusi, Elizabeth A.
dc.contributor.authorCohen, Craig R.
dc.contributor.authorKatabira, Elly
dc.contributor.authorRonald, Allan
dc.contributor.authorKiarie, James
dc.contributor.authorFarquhar, Carey
dc.contributor.authorStewart, Grace John
dc.contributor.authorWere, Edwin
dc.contributor.authorFife, Kenneth
dc.contributor.authordeBruyn, Guy
dc.contributor.authorGray, Glenda
dc.contributor.authorManongi, Rachel
dc.contributor.authorCoetzee, David
dc.contributor.authorAllen, Susan
dc.contributor.authorInambao, Mubiana
dc.contributor.authorKayitenkore, Kayitesi
dc.contributor.authorKarita, Etienne
dc.contributor.authorKanweka, William
dc.contributor.authorDelany, Sinead
dc.contributor.authorRees, Helen
dc.contributor.authorVwalika, Bellington
dc.contributor.authorCoombs, Robert W.
dc.contributor.authorMorrow, Rhoda
dc.contributor.authorWhittington, William
dc.contributor.authorCorey, Lawrence
dc.contributor.authorWald, Anna
dc.contributor.authorCelum, Connie
dc.contributor.authorEmery, Sean
dc.contributor.authorMakhema, Joseph Moeketsi
dc.contributor.authorEssex, Myron Elmer
dc.contributor.authorMcIntyre, James Francis
dc.contributor.authorKapiga, Saidi Hussein
dc.date.accessioned2010-11-16T15:06:33Z
dc.date.issued2009
dc.identifier.citationLingappa, Jairam R., Erin Kahle, Nelly Mugo, Andrew Mujugira, Amalia Magaret, Jared Baeten, Elizabeth A. Bukusi, et al. 2009. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE 4(4): e5272.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4555908
dc.description.abstractBackground: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. Methods: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. Results: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2–9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (<5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462 cells/mcL and median HIV-1 plasma RNA was 4.2 log10 copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log10 copies/mL; p<0.001) and CD4 count (−0.25 and −0.55 log10 copies/mL for CD4 350–499 and >500 relative to <350, respectively, p<0.001). Conclusions: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission. Trial Registration ClinicalTrials.gov NCT00194519en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0005272en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671170/pdf/en_US
dash.licenseLAA
dc.subjectpublic health and epidemiologyen_US
dc.subjectpreventive medicineen_US
dc.subjectinfectious diseasesen_US
dc.subjectsexually transmitted diseasesen_US
dc.subjectHIV infection and AIDSen_US
dc.titleCharacteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorMakhema, Joseph Moeketsi
dc.date.available2010-11-16T15:06:33Z
dash.affiliation.otherSPH^Immunology and Infectious Diseasesen_US
dash.affiliation.otherSPH^Immunology and Infectious Diseasesen_US
dc.identifier.doi10.1371/journal.pone.0005272*
dash.authorsorderedfalse
dash.contributor.affiliatedMcIntyre, James
dash.contributor.affiliatedKapiga, Saidi Hussein
dash.contributor.affiliatedMakhema, Joseph
dash.contributor.affiliatedEssex, Myron


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