dc.contributor.author | Lingappa, Jairam R. | |
dc.contributor.author | Kahle, Erin | |
dc.contributor.author | Mugo, Nelly | |
dc.contributor.author | Mujugira, Andrew | |
dc.contributor.author | Magaret, Amalia | |
dc.contributor.author | Baeten, Jared | |
dc.contributor.author | Bukusi, Elizabeth A. | |
dc.contributor.author | Cohen, Craig R. | |
dc.contributor.author | Katabira, Elly | |
dc.contributor.author | Ronald, Allan | |
dc.contributor.author | Kiarie, James | |
dc.contributor.author | Farquhar, Carey | |
dc.contributor.author | Stewart, Grace John | |
dc.contributor.author | Were, Edwin | |
dc.contributor.author | Fife, Kenneth | |
dc.contributor.author | deBruyn, Guy | |
dc.contributor.author | Gray, Glenda | |
dc.contributor.author | Manongi, Rachel | |
dc.contributor.author | Coetzee, David | |
dc.contributor.author | Allen, Susan | |
dc.contributor.author | Inambao, Mubiana | |
dc.contributor.author | Kayitenkore, Kayitesi | |
dc.contributor.author | Karita, Etienne | |
dc.contributor.author | Kanweka, William | |
dc.contributor.author | Delany, Sinead | |
dc.contributor.author | Rees, Helen | |
dc.contributor.author | Vwalika, Bellington | |
dc.contributor.author | Coombs, Robert W. | |
dc.contributor.author | Morrow, Rhoda | |
dc.contributor.author | Whittington, William | |
dc.contributor.author | Corey, Lawrence | |
dc.contributor.author | Wald, Anna | |
dc.contributor.author | Celum, Connie | |
dc.contributor.author | Emery, Sean | |
dc.contributor.author | Makhema, Joseph Moeketsi | |
dc.contributor.author | Essex, Myron Elmer | |
dc.contributor.author | McIntyre, James Francis | |
dc.contributor.author | Kapiga, Saidi Hussein | |
dc.date.accessioned | 2010-11-16T15:06:33Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Lingappa, Jairam R., Erin Kahle, Nelly Mugo, Andrew Mujugira, Amalia Magaret, Jared Baeten, Elizabeth A. Bukusi, et al. 2009. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE 4(4): e5272. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4555908 | |
dc.description.abstract | Background: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. Methods: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. Results: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2–9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (<5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462 cells/mcL and median HIV-1 plasma RNA was 4.2 log10 copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log10 copies/mL; p<0.001) and CD4 count (−0.25 and −0.55 log10 copies/mL for CD4 350–499 and >500 relative to <350, respectively, p<0.001). Conclusions: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission. Trial Registration ClinicalTrials.gov NCT00194519 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0005272 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671170/pdf/ | en_US |
dash.license | LAA | |
dc.subject | public health and epidemiology | en_US |
dc.subject | preventive medicine | en_US |
dc.subject | infectious diseases | en_US |
dc.subject | sexually transmitted diseases | en_US |
dc.subject | HIV infection and AIDS | en_US |
dc.title | Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Makhema, Joseph Moeketsi | |
dc.date.available | 2010-11-16T15:06:33Z | |
dash.affiliation.other | SPH^Immunology and Infectious Diseases | en_US |
dash.affiliation.other | SPH^Immunology and Infectious Diseases | en_US |
dc.identifier.doi | 10.1371/journal.pone.0005272 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | McIntyre, James | |
dash.contributor.affiliated | Kapiga, Saidi Hussein | |
dash.contributor.affiliated | Makhema, Joseph | |
dash.contributor.affiliated | Essex, Myron | |