Plasma Phyto-Oestrogens and Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

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Plasma Phyto-Oestrogens and Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

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Title: Plasma Phyto-Oestrogens and Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Author: Travis, R C; Appleby, P N; Roddam, A W; Overvad, K; Johnsen, N F; Kaaks, R; Linseisen, J; Boeing, H; Nöthlings, U; Bueno-de-Mesquita, H B; Ros, M M; Sacerdote, C; Palli, D; Tumino, R; Berrino, F; Trichopoulou, A; Dilis, V; Chirlaque, M-D; Ardanaz, E; Larranaga, N; Suárez, L R; Sánchez, M-J; Bingham, S; Khaw, K-T; Hallmans, G; Stattin, P; Rinaldi, S; Slimani, N; Jenab, M; Riboli, E; Key, T J; Spencer, E A; Allen, N E; Olsen, A; Trichopoulos, Dimitrios; Gonzalez, C

Note: Order does not necessarily reflect citation order of authors.

Citation: Travis, R. C., E. A. Spencer, N. E. Allen, P. N. Appleby, A. W. Roddam, K. Overvad, N. F. Johnsen, et al. 2009. Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition. British Journal of Cancer 100(11): 1817-1823.
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Abstract: We examined plasma concentrations of phyto-oestrogens in relation to risk for subsequent prostate cancer in a case–control study nested in the European Prospective Investigation into Cancer and Nutrition. Concentrations of isoflavones genistein, daidzein and equol, and that of lignans enterolactone and enterodiol, were measured in plasma samples for 950 prostate cancer cases and 1042 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of these phyto-oestrogens were estimated by conditional logistic regression. Higher plasma concentrations of genistein were associated with lower risk of prostate cancer: RR among men in the highest vs the lowest fifth, 0.71 (95% confidence interval (CI) 0.53–0.96, P trend=0.03). After adjustment for potential confounders this RR was 0.74 (95% CI 0.54–1.00, P trend=0.05). No statistically significant associations were observed for circulating concentrations of daidzein, equol, enterolactone or enterodiol in relation to overall risk for prostate cancer. There was no evidence of heterogeneity in these results by age at blood collection or country of recruitment, nor by cancer stage or grade. These results suggest that higher concentrations of circulating genistein may reduce the risk of prostate cancer but do not support an association with plasma lignans.
Published Version: doi://10.1038/sj.bjc.6605073
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685599/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4578955
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