Show simple item record

dc.contributor.authorBjørling-Poulsen, Marina
dc.contributor.authorAndersen, Helle Raun
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2010-11-22T15:01:23Z
dc.date.issued2008
dc.identifier.citationBjørling-Poulsen, Marina, Helle Raun Andersen, and Philippe Grandjean. 2008. Potential developmental neurotoxicity of pesticides used in Europe. Environmental Health 7:50.en_US
dc.identifier.issn1476-069Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4584624
dc.description.abstractPesticides used in agriculture are designed to protect crops against unwanted species, such as weeds, insects, and fungus. Many compounds target the nervous system of insect pests. Because of the similarity in brain biochemistry, such pesticides may also be neurotoxic to humans. Concerns have been raised that the developing brain may be particularly vulnerable to adverse effects of neurotoxic pesticides. Current requirements for safety testing do not include developmental neurotoxicity. We therefore undertook a systematic evaluation of published evidence on neurotoxicity of pesticides in current use, with specific emphasis on risks during early development. Epidemiologic studies show associations with neurodevelopmental deficits, but mainly deal with mixed exposures to pesticides. Laboratory experimental studies using model compounds suggest that many pesticides currently used in Europe – including organophosphates, carbamates, pyrethroids, ethylenebisdithiocarbamates, and chlorophenoxy herbicides – can cause neurodevelopmental toxicity. Adverse effects on brain development can be severe and irreversible. Prevention should therefore be a public health priority. The occurrence of residues in food and other types of human exposures should be prevented with regard to the pesticide groups that are known to be neurotoxic. For other substances, given their widespread use and the unique vulnerability of the developing brain, the general lack of data on developmental neurotoxicity calls for investment in targeted research. While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1476-069X-7-50en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577708/pdf/en_US
dash.licenseLAA
dc.titlePotential Developmental Neurotoxicity of Pesticides used in Europeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Healthen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2010-11-22T15:01:23Z
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1186/1476-069X-7-50*
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record