Intrauterine Environment, Mammary Gland Mass and Breast Cancer Risk

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Intrauterine Environment, Mammary Gland Mass and Breast Cancer Risk

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Title: Intrauterine Environment, Mammary Gland Mass and Breast Cancer Risk
Author: Trichopoulos, Dimitrios
Citation: Trichopoulos, Dimitrios. 2003. Intrauterine environment, mammary gland mass and breast cancer risk. Breast Cancer Research 5(1): 42-44.
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Abstract: Two intimately linked hypotheses on breast cancer etiology are described. The main postulate of the first hypothesis is that higher levels of pregnancy estrogens and other hormones favor the generation of a higher number of susceptible stem cells with compromised genomic stability. The second hypothesis postulates that the mammary gland mass, as a correlate of the number of cells susceptible to transformation, is an important determinant of breast cancer risk. A simple integrated etiological model for breast cancer is presented and it is indicated that the model accommodates most epidemiological aspects of breast cancer occurrence and natural history.
Published Version: doi:10.1186/bcr555
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154134/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4591582
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