(A)Symmetric Stem Cell Replication and Cancer

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(A)Symmetric Stem Cell Replication and Cancer

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Title: (A)Symmetric Stem Cell Replication and Cancer
Author: Dingli, David; Traulsen, Arne; Michor, Franziska L.

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Citation: Dingli, David, Arne Traulsen and Franziska Michor. 2007. (A)Symmetric stem cell replication and cancer. PLoS Computational Biology 3(3): e53.
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Abstract: Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Since cellular replication is associated with an inherent risk of mutagenesis, tissues are maintained by a small group of stem cells (SCs) that replicate slowly to maintain their own population and that give rise to differentiated cells. There is increasing evidence that many tumors are also maintained by a small population of cancer stem cells that may arise by mutations from normal SCs. SC replication can be either symmetric or asymmetric. The former can lead to expansion of the SC pool. We describe a simple model to evaluate the impact of (a)symmetric SC replication on the expansion of mutant SCs and to show that mutations that increase the probability of asymmetric replication can lead to rapid mutant SC expansion in the absence of a selective fitness advantage. Mutations in several genes can lead to this process and may be at the root of the carcinogenic process.
Published Version: doi:10.1371/journal.pcbi.0030053
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828703/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4595105
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