Childhood Physical Abnormalities Following Paternal Exposure to Sulfur Mustard Gas in Iran: A Case-control Study

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Childhood Physical Abnormalities Following Paternal Exposure to Sulfur Mustard Gas in Iran: A Case-control Study

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Title: Childhood Physical Abnormalities Following Paternal Exposure to Sulfur Mustard Gas in Iran: A Case-control Study
Author: Abolghasemi, Hassan; Radfar, Mohammad H; Rambod, Mehdi; Salehi, Parvin; Ghofrani, Hossein; Soroush, Mohammad R; Falahaty, Farahnaz; Tavakolifar, Yousef; Sadaghianifar, Ali; Khademolhosseini, Seyyed M; Kavehmanesh, Zohreh; Joffres, Michel; Mills, Edward J; Burkle, Frederick

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Citation: Abolghasemi, Hassan, Mohammad H. Radfar, Mehdi Rambod, Parvin Salehi, Hossein Ghofrani, Mohammad R. Soroush, Farahnaz Falahaty, et al. 2010. Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: a case-control study. Conflict and Health 4:13.
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Abstract: Background: Mustard gas, a known chemical weapon, was used during the Iran-Iraq war of 1980-1988. We aimed to determine if exposure to mustard gas among men was significantly associated with abnormalities and disorders among progenies. Methods: Using a case-control design, we identified all progenies of Sardasht men (exposed group, n = 498), who were born at least nine months after the exposure, compared to age-matched controls in Rabat, a nearby city (non-exposed group, n = 689). We conducted a thorough medical history, physical examination, and appropriate paraclinical studies to detect any physical abnormality and/or disorder. Given the presence of correlated data, we applied Generalized Estimating Equation (GEE) multivariable models to determine associations. Results: The overall frequency of detected physical abnormalities and disorders was significantly higher in the exposed group (19% vs. 11%, Odds Ratio [OR] 1.93, 95% Confidence Interval [CI], 1.37-2.72, P = 0.0002). This was consistent across sexes. Congenital anomalies (OR 3.54, 95% CI, 1.58-7.93, P = 0.002) and asthma (OR, 3.12, 95% CI, 1.43-6.80, P = 0.004) were most commonly associated with exposure. No single abnormality was associated with paternal exposure to mustard gas. Conclusion: Our study demonstrates a generational effect of exposure to mustard gas. The lasting effects of mustard gas exposure in parents effects fertility and may impact child health and development in the long-term.
Published Version: doi:10.1186/1752-1505-4-13
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917398/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4595153
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