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dc.contributor.authorMeeker, John D.
dc.contributor.authorRyan, Louise Marie
dc.contributor.authorBarr, Dana B.
dc.contributor.authorHerrick, Robert F.
dc.contributor.authorBennett, Deborah H.
dc.contributor.authorBravo, Roberto
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2010-12-02T21:22:51Z
dc.date.issued2004
dc.identifier.citationMeeker, John D., Louise Ryan, Dana B. Barr, Robert F. Herrick, Deborah H. Bennett, Roberto Bravo, and Russ Hauser. 2004. The relationship of urinary metabolites of Carbaryl/Naphthalene and Chlorpyrifos with human semen quality. Environmental Health Perspectives 112(17): 1665-1670.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4596639
dc.description.abstractMost of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n = 272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N concentrations were 3.22 and 3.19 μg/L, respectively. For increasing 1N tertiles, adjusted odds ratios (ORs) were significantly elevated for below-reference sperm concentration (OR for low, medium, and high tertiles = 1.0, 4.2, 4.2, respectively; p-value for trend = 0.01) and percent motile sperm (1.0, 2.5, 2.4; p-value for trend = 0.01). The sperm motion parameter most strongly associated with 1N was straight-line velocity. There were suggestive, borderline-significant associations for TCPY with sperm concentration and motility, whereas sperm morphology was weakly and nonsignificantly associated with both TCPY and 1N. The observed associations between altered semen quality and 1N are consistent with previous studies of carbaryl exposure, although suggestive associations with TCPY are difficult to interpret because human and animal data are currently limited.en_US
dc.language.isoen_USen_US
dc.publisherThe National Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.7234en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253656/pdf/en_US
dash.licenseLAA
dc.subjectbiological markersen_US
dc.subjectenvironmenten_US
dc.subjecthumanen_US
dc.subjectpesticidesen_US
dc.subjectsemenen_US
dc.titleThe Relationship of Urinary Metabolites of Carbaryl/Naphthalene and Chlorpyrifos with Human Semen Qualityen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHauser, Russ B.
dc.date.available2010-12-02T21:22:51Z
dash.affiliation.otherSPH^Biostatisticsen_US
dc.identifier.doi10.1289/ehp.7234*
dash.contributor.affiliatedRyan, Louise
dash.contributor.affiliatedHerrick, Robert
dash.contributor.affiliatedHauser, Russ


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