Integrating Complex Genomic Datasets and Tumour Cell Sensitivity Profiles to Address a 'Simple' Question: Which Patients Should Get this Drug?

DSpace/Manakin Repository

Integrating Complex Genomic Datasets and Tumour Cell Sensitivity Profiles to Address a 'Simple' Question: Which Patients Should Get this Drug?

Citable link to this page

 

 
Title: Integrating Complex Genomic Datasets and Tumour Cell Sensitivity Profiles to Address a 'Simple' Question: Which Patients Should Get this Drug?
Author: Benes, Cyril Henri; Settleman, Jeffrey Evan

Note: Order does not necessarily reflect citation order of authors.

Citation: Benes, Cyril, and Jeff Settleman. 2009. Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?. BMC Medicine 7:78.
Full Text & Related Files:
Abstract: It is becoming increasingly apparent that cancer drug therapies can only reach their full potential through appropriate patient selection. Matching drugs and cancer patients has proven to be a complex challenge, due in large part to the substantial molecular heterogeneity inherent to human cancers. This is not only a major hurdle to the improvement of the use of current treatments but also for the development of novel therapies and the ability to steer them to the relevant clinical indications. In this commentary we discuss recent studies from Kuo et al., published this month in BMC Medicine, in which they used a panel of cancer cell lines as a model for capturing patient heterogeneity at the genomic and proteomic level in order to identify potential biomarkers for predicting the clinical activity of a novel candidate chemotherapeutic across a patient population. The findings highlight the ability of a 'systems approach' to develop a better understanding of the properties of novel candidate therapeutics and to guide clinical testing and application. See the associated research paper by Kuo et al: http://www.biomedcentral.com/1741-7015/7/77
Published Version: doi:10.1186/1741-7015-7-78
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799438/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621014
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters