A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis
View/ Open
Author
Chen, Crystal Y.
Shen, Ling
Zeng, Gucheng
Yao, Shuyun
Shen, Yun
Halliday, Lisa
Fortman, Jeff
McAllister, Milton
Estep, Jim
Vasconcelos, Daphne
Du, George
Porcelli, Steven A.
Larsen, Michelle H.
Jacobs, William R.
Haynes, Barton F.
Huang, Dan
Wang, Richard
Hunt, Robert
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1371/journal.ppat.1000392Metadata
Show full item recordCitation
Chen, Crystal Y., Dan Huang, Richard C. Wang, Ling Shen, Gucheng Zeng, Shuyun Yao, Yun Shen, et al. 2009. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathogens 5(4): e1000392.Abstract
The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the specificity and functions of CD8 T cells, such as the expression of group 1 CD1 proteins that are capable of presenting Mycobacterium tuberculosis lipids antigens and the cytotoxic/bactericidal protein granulysin. Employing a more relevant nonhuman primate model of human tuberculosis, we examined the contribution of BCG- or M. tuberculosis-elicited CD8 T cells to vaccine-induced immunity against tuberculosis. CD8 depletion compromised BCG vaccine-induced immune control of M. tuberculosis replication in the vaccinated rhesus macaques. Depletion of CD8 T cells in BCG-vaccinated rhesus macaques led to a significant decrease in the vaccine-induced immunity against tuberculosis. Consistently, depletion of CD8 T cells in rhesus macaques that had been previously infected with M. tuberculosis and cured by antibiotic therapy also resulted in a loss of anti-tuberculosis immunity upon M. tuberculosis re-infection. The current study demonstrates a major role for CD8 T cells in anti-tuberculosis immunity, and supports the view that CD8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663842/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621016
Collections
- HMS Scholarly Articles [17918]
Contact administrator regarding this item (to report mistakes or request changes)