A Method for High-Throughput Gene Expression Signature Analysis

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A Method for High-Throughput Gene Expression Signature Analysis

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Title: A Method for High-Throughput Gene Expression Signature Analysis
Author: Peck, David; Crawford, Emily D; Ross, Kenneth N; Stegmaier, Kimberly; Golub, Todd R.; Lamb, Justin

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Citation: Peck, David, Emily D. Crawford, Kenneth N. Ross, Kimberly Stegmaier, Todd R. Golub, and Justin Lamb. 2006. A method for high-throughput gene expression signature analysis. Genome Biology 7(7): R61.
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Abstract: Genome-wide transcriptional profiling has shown that different biologic states (for instance, disease and response to pharmacologic manipulation) can be recognized by the expression pattern of relatively small numbers of genes. However, the lack of a practical and cost-effective technology for detection of these gene expression 'signatures' in large numbers of samples has severely limited their exploitation in important medical and pharmaceutical discovery applications. Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system.
Published Version: doi: 10.1186/gb-2006-7-7-r61
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779561/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621133
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