Comparison of Evoked vs. Spontaneous Tics in a Patient with Trigeminal Neuralgia (Tic Doloureux)

DSpace/Manakin Repository

Comparison of Evoked vs. Spontaneous Tics in a Patient with Trigeminal Neuralgia (Tic Doloureux)

Citable link to this page

 

 
Title: Comparison of Evoked vs. Spontaneous Tics in a Patient with Trigeminal Neuralgia (Tic Doloureux)
Author: Pendse, Gautam; Morris, Susie; Aiello-Lammens, Matthew; Scrivani, Steven; Borsook, David; Moulton, Eric Alan; Cole, Sadie Hannah; Becerra, Lino Renan

Note: Order does not necessarily reflect citation order of authors.

Citation: Borsook, David, Eric A. Moulton, Gautam Pendse, Susie Morris, Sadie H. Cole, Matthew Aiello-Lammens, Steven Scrivani, and Lino R. Becerra. 2007. Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Molecular Pain 3:34.
Full Text & Related Files:
Abstract: A 53-year old woman with tic doloureaux, affecting her right maxillary division of the trigeminal nerve (V2), could elicit shooting pains by slightly tapping her teeth when off medication. The pains, which she normally rated as > 6/10 on a visual analog scale (VAS), were electric shock-like in nature. She had no other spontaneous or ongoing background pain affecting the region. Based on her ability to elicit these tics, functional magnetic resonance imaging (fMRI) was performed while she produced brief shocks every 2 minutes on cue (evoked pain) over a 20 min period. In addition, she had 1–2 spontaneous shocks manifested between these evoked pains over the course of functional image acquisition. Increased fMRI activation for both evoked and spontaneous tics was observed throughout cortical and subcortical structures commonly observed in experimental pain studies with healthy subjects; including the primary somatosensory cortex, insula, anterior cingulate, and thalamus. Spontaneous tics produced more decrease in signals in a number of regions including the posterior cingulate cortex and amygdala, suggesting that regions known to be involved in expectation/anticipation may have been activated for the evoked, but not spontaneous, tics. In this patient there were large increases in activation observed in the frontal regions, including the anterior cingulate cortex and the basal ganglia. Spontaneous tics showed increased activation in classic aversion circuitry that may contribute to increased levels of anxiety. We believe that this is the first report of functional imaging of brain changes in tic-doloureaux.
Published Version: doi: 10.1186/1744-8069-3-34
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217520/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621152
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters