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dc.contributor.authorLiu, Zhirong
dc.contributor.authorDeibler, Richard Wendel
dc.contributor.authorChan, Hue Sun
dc.contributor.authorZechiedrich, Lynn
dc.date.accessioned2010-12-09T20:16:24Z
dc.date.issued2009
dc.identifier.citationLiu, Zhirong, Richard W. Deibler, Hue Sun Chan, and Lynn Zechiedrich. 2009. The why and how of DNA unlinking. Nucleic Acids Research 37(3): 661-671.en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4621863
dc.description.abstractThe nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control of gene transcription, faithful DNA replication and segregation, maintenance of the genome and cellular differentiation are subject to the conformational and topological properties of DNA in addition to the regulation imparted by the sequence itself. How do these DNA features manifest such striking effects and how does the cell regulate them? In this review, we describe how misregulation of DNA topology can lead to cellular dysfunction. We then address how cells prevent these topological problems. We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/nar/gkp041en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647305/pdf/en_US
dash.licenseLAA
dc.titleThe Why and How of DNA Unlinkingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNucleic Acids Researchen_US
dash.depositing.authorDeibler, Richard Wendel
dc.date.available2010-12-09T20:16:24Z
dash.affiliation.otherHMS^Systems Biologyen_US
dc.identifier.doi10.1093/nar/gkp041*
dash.contributor.affiliatedDeibler, Richard Wendel


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