Show simple item record

dc.contributor.authorCai, Xuezhong
dc.contributor.authorSchäfer, Alexandra
dc.contributor.authorLu, Shihua
dc.contributor.authorBilello, John P
dc.contributor.authorDesrosiers, Ronald C.
dc.contributor.authorEdwards, Rachel
dc.contributor.authorRaab-Traub, Nancy
dc.contributor.authorCullen, Bryan R
dc.date.accessioned2010-12-10T14:45:08Z
dc.date.issued2006
dc.identifier.citationCai, Xuezhong, Alexandra Schäfer, Shihua Lu, John P. Bilello, Ronald C. Desrosiers, Rachel Edwards, Nancy Raab-Traub, and Bryan R. Cullen. 2006. Epstein–Barr Virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathogens 2(3): e23.en_US
dc.identifier.issn1553-7366en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4621952
dc.description.abstractThe pathogenic lymphocryptovirus Epstein–Barr virus (EBV) is shown to express at least 17 distinct microRNAs (miRNAs) in latently infected cells. These are arranged in two clusters: 14 miRNAs are located in the introns of the viral BART gene while three are located adjacent to BHRF1. The BART miRNAs are expressed at high levels in latently infected epithelial cells and at lower, albeit detectable, levels in B cells. In contrast to the tissue-specific expression pattern of the BART miRNAs, the BHRF1 miRNAs are found at high levels in B cells undergoing stage III latency but are essentially undetectable in B cells or epithelial cells undergoing stage I or II latency. Induction of lytic EBV replication was found to enhance the expression of many, but not all, of these viral miRNAs. Rhesus lymphocryptovirus, which is separated from EBV by ≥13 million years of evolution, expresses at least 16 distinct miRNAs, seven of which are closely related to EBV miRNAs. Thus, lymphocryptovirus miRNAs are under positive selection and are likely to play important roles in the viral life cycle. Moreover, the differential regulation of EBV miRNA expression implies distinct roles during infection of different human tissues.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.ppat.0020023en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409806/pdf/en_US
dash.licenseLAA
dc.subjectinfectious diseasesen_US
dc.subjectmicrobiologyen_US
dc.subjectmolecular biologyen_US
dc.subjectstructural biologyen_US
dc.subjectvirologyen_US
dc.subjectvirusesen_US
dc.subjecteukayotesen_US
dc.subjectanimalsen_US
dc.subjecthomo (human)en_US
dc.subjectprimatesen_US
dc.titleEpstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expresseden_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Pathogensen_US
dash.depositing.authorDesrosiers, Ronald C.
dc.date.available2010-12-10T14:45:08Z
dash.affiliation.otherHMS^New England Primate Research Centeren_US
dash.affiliation.otherHMS^Microbiology and Molecular Geneticsen_US
dc.identifier.doi10.1371/journal.ppat.0020023*
dash.contributor.affiliatedDesrosiers, Ronald


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record