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dc.contributor.authorFrangeul, Lionel
dc.contributor.authorQuillardet, Philippe
dc.contributor.authorCastets, Anne-Marie
dc.contributor.authorHumbert, Jean-François
dc.contributor.authorMatthijs, Hans CP
dc.contributor.authorCortez, Diego
dc.contributor.authorZhang, Cheng-Cai
dc.contributor.authorGribaldo, Simonetta
dc.contributor.authorKehr, Jan-Christoph
dc.contributor.authorZilliges, Yvonne
dc.contributor.authorZiemert, Nadine
dc.contributor.authorBecker, Sven
dc.contributor.authorTalla, Emmanuel
dc.contributor.authorLatifi, Amel
dc.contributor.authorBillault, Alain
dc.contributor.authorLepelletier, Anthony
dc.contributor.authorDittmann, Elke
dc.contributor.authorBouchier, Christiane
dc.contributor.authorTandeau de Marsac, Nicole
dc.contributor.authorTolonen, Andrew
dc.date.accessioned2011-02-10T20:34:41Z
dc.date.issued2008
dc.identifier.citationFrangeul, Lionel, Philippe Quillardet, Anne-Marie Castets, Jean-François Humbert, Hans C. P. Matthijs, Diego Cortez, Andrew Tolonen, et al. 2008. Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium. BMC Genomics 9: 274.en_US
dc.identifier.issn1471-2164en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4724154
dc.description.abstractBackground: The colonial cyanobacterium Microcystis proliferates in a wide range of freshwater ecosystems and is exposed to changing environmental factors during its life cycle. Microcystis blooms are often toxic, potentially fatal to animals and humans, and may cause environmental problems. There has been little investigation of the genomics of these cyanobacteria. Results: Deciphering the 5,172,804 bp sequence of Microcystis aeruginosa PCC 7806 has revealed the high plasticity of its genome: 11.7% DNA repeats containing more than 1,000 bases, 6.8% putative transposases and 21 putative restriction enzymes. Compared to the genomes of other cyanobacterial lineages, strain PCC 7806 contains a large number of atypical genes that may have been acquired by lateral transfers. Metabolic pathways, such as fermentation and a methionine salvage pathway, have been identified, as have genes for programmed cell death that may be related to the rapid disappearance of Microcystis blooms in nature. Analysis of the PCC 7806 genome also reveals striking novel biosynthetic features that might help to elucidate the ecological impact of secondary metabolites and lead to the discovery of novel metabolites for new biotechnological applications. M. aeruginosa and other large cyanobacterial genomes exhibit a rapid loss of synteny in contrast to other microbial genomes. Conclusion: Microcystis aeruginosa PCC 7806 appears to have adopted an evolutionary strategy relying on unusual genome plasticity to adapt to eutrophic freshwater ecosystems, a property shared by another strain of M. aeruginosa (NIES-843). Comparisons of the genomes of PCC 7806 and other cyanobacterial strains indicate that a similar strategy may have also been used by the marine strain Crocosphaera watsonii WH8501 to adapt to other ecological niches, such as oligotrophic open oceans.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2164-9-274en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442094/pdf/en_US
dash.licenseLAA
dc.titleHighly Plastic Genome of Microcystis aeruginosa PCC 7806, a Ubiquitous Toxic Freshwater Cyanobacteriumen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Genomicsen_US
dash.depositing.authorTolonen, Andrew
dc.date.available2011-02-10T20:34:41Z
dash.affiliation.otherHMS^Geneticsen_US
dc.identifier.doi10.1186/1471-2164-9-274*
dash.authorsorderedfalse
dash.contributor.affiliatedTolonen, Andrew


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