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dc.contributor.authorPark, Peter J.
dc.contributor.authorKong, Sek Won Won
dc.contributor.authorTebaldi, Toma
dc.contributor.authorLai, Weil R.
dc.contributor.authorKasif, Simon
dc.contributor.authorKohane, Isaac Samuel
dc.date.accessioned2011-02-11T21:13:54Z
dc.date.issued2009
dc.identifier.citationPark, Peter J., Sek Won Kong, Toma Tebaldi, Weil R. Lai, Simon Kasif, and Isaac S. Kohane. 2009. Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance. Bioinformatics 25(23): 3121-3127.en_US
dc.identifier.issn1367-4803en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4724756
dc.description.abstractMotivation: Type 2 diabetes is a chronic metabolic disease that involves both environmental and genetic factors. To understand the genetics of type 2 diabetes and insulin resistance, the DIabetes Genome Anatomy Project (DGAP) was launched to profile gene expression in a variety of related animal models and human subjects. We asked whether these heterogeneous models can be integrated to provide consistent and robust biological insights into the biology of insulin resistance. Results: We perform integrative analysis of the 16 DGAP data sets that span multiple tissues, conditions, array types, laboratories, species, genetic backgrounds and study designs. For each data set, we identify differentially expressed genes compared with control. Then, for the combined data, we rank genes according to the frequency with which they were found to be statistically significant across data sets. This analysis reveals RetSat as a widely shared component of mechanisms involved in insulin resistance and sensitivity and adds to the growing importance of the retinol pathway in diabetes, adipogenesis and insulin resistance. Top candidates obtained from our analysis have been confirmed in recent laboratory studies. Contact: Isaac_kohane@harvard.eduen_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/bioinformatics/btp559en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778339/pdf/en_US
dash.licenseLAA
dc.subjectgene expressionen_US
dc.titleIntegration of Heterogeneous Expression Data Sets Extends the Role of the Retinol Pathway in Diabetes and Insulin Resistanceen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBioinformaticsen_US
dash.depositing.authorPark, Peter J.
dc.date.available2011-02-11T21:13:54Z
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dash.affiliation.otherHMS^Countway Library of Medicineen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1093/bioinformatics/btp559*
dash.contributor.affiliatedKong, Sek Won
dash.contributor.affiliatedPark, Peter
dash.contributor.affiliatedKohane, Isaac


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