Mammalian Sleep Dynamics: How Diverse Features Arise From a Common Physiological Framework

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Mammalian Sleep Dynamics: How Diverse Features Arise From a Common Physiological Framework

Show simple item record Robinson, Peter A. Kedziora, David J. Abeysuriya, Romesh G. Friston, Karl J. Phillips, Andrew J. 2011-02-11T21:20:44Z 2010
dc.identifier.citation Phillips, Andrew J. K., Peter A. Robinson, David J. Kedziora, and Romesh G. Abeysuriya. 2010. Mammalian sleep dynamics: How diverse features arise from a common physiological framework. PLoS Computational Biology 6(6): e1000826. en_US
dc.identifier.issn 1553-734X en_US
dc.identifier.issn 1553-7358 en_US
dc.description.abstract Mammalian sleep varies widely, ranging from frequent napping in rodents to consolidated blocks in primates and unihemispheric sleep in cetaceans. In humans, rats, mice and cats, sleep patterns are orchestrated by homeostatic and circadian drives to the sleep–wake switch, but it is not known whether this system is ubiquitous among mammals. Here, changes of just two parameters in a recent quantitative model of this switch are shown to reproduce typical sleep patterns for 17 species across 7 orders. Furthermore, the parameter variations are found to be consistent with the assumptions that homeostatic production and clearance scale as brain volume and surface area, respectively. Modeling an additional inhibitory connection between sleep-active neuronal populations on opposite sides of the brain generates unihemispheric sleep, providing a testable hypothetical mechanism for this poorly understood phenomenon. Neuromodulation of this connection alone is shown to account for the ability of fur seals to transition between bihemispheric sleep on land and unihemispheric sleep in water. Determining what aspects of mammalian sleep patterns can be explained within a single framework, and are thus universal, is essential to understanding the evolution and function of mammalian sleep. This is the first demonstration of a single model reproducing sleep patterns for multiple different species. These wide-ranging findings suggest that the core physiological mechanisms controlling sleep are common to many mammalian orders, with slight evolutionary modifications accounting for interspecies differences. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi://10.1371/journal.pcbi.1000826 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.subject biophysics en_US
dc.subject theory and simulation en_US
dc.subject computational biology en_US
dc.subject computational neuroscience en_US
dc.subject systems biology en_US
dc.subject evolutionary biology en_US
dc.subject physiology en_US
dc.subject marine and aquatic sciences en_US
dc.title Mammalian Sleep Dynamics: How Diverse Features Arise From a Common Physiological Framework en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Computational Biology en_US Phillips, Andrew J. 2011-02-11T21:20:44Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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