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dc.contributor.authorKhan, Imtiaz A
dc.contributor.authorThomas, Seddon Y
dc.contributor.authorMoretto, Magali M
dc.contributor.authorLee, Frederick S
dc.contributor.authorIslam, Sabina A.
dc.contributor.authorCombe, Crescent
dc.contributor.authorSchwartzman, Joseph D
dc.contributor.authorLuster, Andrew David
dc.date.accessioned2011-02-14T23:52:30Z
dc.date.issued2006
dc.identifier.citationKhan, Imtiaz A., Seddon Y. Thomas, Magali M. Moretto, Frederick S. Lee, Sabina A. Islam, Crescent Combe, Joseph D. Schwartzman, and Andrew D. Luster. 2006. CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection. PLoS Pathogens 2(6): e49.en_US
dc.identifier.issn1553-7366en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4725504
dc.description.abstractThe host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan parasite Toxoplasma gondii. We found that CCR5 controls recruitment of natural killer (NK) cells into infected tissues. Without this influx of NK cells, tissues from CCR5-deficient (CCR5−/−) mice were less able to generate an inflammatory response, had decreased chemokine and interferon γ production, and had higher parasite burden. As a result, CCR5−/− mice were more susceptible to infection with T. gondii but were less susceptible to the immune-mediated tissue injury seen in certain inbred strains. Adoptive transfer of CCR5+/+ NK cells into CCR5−/− mice restored their ability to survive lethal T. gondii infection and demonstrated that CCR5 is required for NK cell homing into infected liver and spleen. This study establishes CCR5 as a critical receptor guiding NK cell trafficking in host defense.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.ppat.0020049en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475660/pdf/en_US
dash.licenseLAA
dc.subjectimmunologyen_US
dc.subjectinfectious diseasesen_US
dc.subjectparasitologyen_US
dc.subjectMus (mouse)en_US
dc.titleCCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infectionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Pathogensen_US
dash.depositing.authorIslam, Sabina A.
dc.date.available2011-02-14T23:52:30Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dc.identifier.doi10.1371/journal.ppat.0020049*
dash.contributor.affiliatedLee, Frederick S
dash.contributor.affiliatedIslam, Sabina
dash.contributor.affiliatedLuster, Andrew


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